Methemoglobin is a form of hemoglobin (HEEM o glo bin). Consult your doctor before breastfeeding. With treatment, symptoms usually go away in less than 24 hours. Tell your caregivers right away if you have: This is not a complete list of side effects and others may occur. Tests may include: People with hemoglobin M disease don’t have symptoms. Overdose symptoms may include vomiting, stomach pain, chest pain or tightness, wheezing, trouble breathing, feeling like you might pass out, fast heart rate, anxiety, confusion, tremor, dilated pupils, blue-colored skin or lips, numbness, or tingling. This is a normal side effect of the medication and will not cause any harm. Call your doctor for medical advice about side effects. Methylene blue is a thiazine dye. This was due to ↓C-GMP levels by Methylene Blue-a potent inhibitor of guanylate cyclase 26). However, do not stop taking your medicine. As no food or respiratory allergy nor skin allergy was identified in the literature search for methylene blue, and concern for anaphylactic reactions upon oral exposure is low, there are no safety concerns with respect to allergenicity of methylene blue 10). Sloand EM, Kessler CM, Mcintosh CL, Klein HG. Complications of methemoglobinemia include: A baby with this condition will have a bluish skin color (cyanosis) at birth or shortly afterward. You may only need to receive one dose of this medicine. Methylene blue due to its monoamine oxidase (MAO) inhibiting property may precipitate potentially fatal serotonin toxicity at doses >5mg/kg 51) and rarely can cause severe anaphylactic shock 52). Call your doctor for medical advice about side effects. Methylene blue also interferes with the pulse oximeter’s light emission resulting in falsely depressed oxygen saturation reading 45). Recent research suggests that Methylene Blue and other redox cyclers induce selective cancer cell apoptosis by NAD (P) H: quinine oxidoreductase (NQO1)-dependent bioreductive generation of cellular oxidative stress. Symptoms of type 1 methemoglobinemia include: Symptoms of type 2 methemoglobinemia include: Symptoms of hemoglobin M disease include: Symptoms of acquired methemoglobinemia include: People with type 1 methemoglobinemia and hemoglobin M disease often do well. Tell your doctor if you are pregnant. However, this effect may cause unusual results with certain urine tests. Call your doctor for medical advice about side effects. 2003;10:289–91. Methylene blue is injected into a vein through an IV. A healthcare provider will give you this injection. 2001;122:823–4. 1995;21:1027–31 https://www.ncbi.nlm.nih.gov/pubmed/8750129. Extinction memory improvement by the metabolic enhancer methylene blue. Methemoglobinemia is a condition in which methemoglobin is present in high levels in the blood. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. See additional information. google_ad_client: "ca-pub-9759235379140764", Methemoglobin normally exists in small amounts in the blood. Malaria Journal. Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Based on the findings of this study 6), patients who continue to show moderate to high levels of fear at the conclusion of an exposure therapy session may have their fear inadvertently strengthened by methylene blue administration, thus leading to a less favorable therapeutic outcome. This medicine works by converting methemoglobin to a more efficient type of hemoglobin to better carry oxygen throughout the body. In most cases of mild acquired methemoglobinemia, no treatment is needed. Methylene blue acts as an alternative electron acceptor, and reverses the NADH inhibition of hepatic gluconeogenesis while also inhibiting the transformation of chloroethylamine into Chloroacetaldehyde, and also inhibits multiple amine oxidase activities, preventing the formation of Chloroacetaldehyde 30). Digestive Disorders: Common Misconceptions, Methylene Blue (Methylene Blue Injection). Migraines: Medical Marijuana and CBD Oils. Redox rep. 2003;8:272–5. See additional information. It works by converting the ferric iron (Fe+++) in hemoglobin to ferrous iron (Fe++). Your blood will also need to be tested to help your doctor determine that the medicine is working. Methemoglobinemia is a condition in which methemoglobin is present in high levels in the blood. You can develop serotonin syndrome if you take methylene blue together with antidepressants called selective serotonin reuptake inhibitors (SSRIs), selective serotonin/norepinephrine reuptake inhibitors (SSNRIs) and monoamine oxidase inhibitors. About how much does an adult human brain weigh? A healthcare provider will give you this injection. Overdose symptoms may include vomiting, stomach pain, chest pain or tightness, wheezing, trouble breathing, feeling like you might pass out, fast heart rate, anxiety, confusion, tremor, dilated pupils, blue-colored skin or lips, numbness, or tingling. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Methemoglobin is a form of hemoglobin. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Methylene blue is injected into a vein through an IV. Apart from the intrinsic antimalarial activity and chloroquine sensitizing action it was also considered to prevent methemoglobinemia- a serious complication of malarial anemia 28). Untreated, serotonin syndrome can be deadly. Methylene blue (1%) has been used IV over 30 min in ICU 1hour before surgery and found decreased incidence and severity of vasoplegic syndrome in high risk patients 20). This can cause severe kidney damage if serotonin syndrome isn’t recognized and treated properly. Call your doctor for medical advice about side effects. It tells you about the potential risk of serotonin syndrome. Preoperative methylene blue administration in patients at high risk for vasoplegic syndrome during cardiac surgery. 2012;96(1):32-45. doi:10.1016/j.pneurobio.2011.10.007. A release of nitric oxide has been incriminated in the cardiovascular alterations of septic shock. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. What is the most important information I should know about methylene blue?